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NSF/ANSI 455-2-2018

Good Manufacturing Practices for Dietary Supplements

This Standard is intended to define a standardized approach for auditing to determine the level of compliance of dietary supplement products to 21 CFR 111 Current Good Manufacturing Practices (GMPs) in Manufacturing, Packaging, Labeling, or Holding Operations for Dietary Supplements as well as incorporating additional retailer requirements. It refers to the requirements for GMP applicable to all dietary supplements. It will assist in the determination of adequate facilities and controls for dietary supplement manufacture with sufficient quality to ensure suitability for intended use.

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As the voice of the U.S. standards and conformity assessment system, the American National Standards Institute (ANSI) empowers its members and constituents to strengthen the U.S. marketplace position in the global economy while helping to assure the safety and health of consumers and the protection of the environment.

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