Historical

MM07-A

Fluorescence In Situ Hybridization (FISH) Methods for Medical Genetics; Approved Guideline

Fluorescence in situ hybridization (FISH) may be used to detect cytogenetic aberrations that are not readily evident by standard cytogenetic banding analyses. FISH technology allows for rapid identification of deletions, duplications, amplifications, and structural abnormalities of specific genes, loci, or chromosomal DNA/RNA sequences. The regions assessed by FISH are typically larger than those studied with polymerase chain reaction (PCR), yet smaller than those visualized microscopically with standard cytogenetics. FISH studies have become routine in medical genetics laboratories and this NCCLS guideline provides information to ensure appropriate and reliable use of the technology.

CONTENT PROVIDER
Clinical And Laboratory Standards Institute [clsi]

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