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NSF/ANSI 455-2-2022

Good Manufacturing Practices for Dietary Supplements

This standard is intended to define a standardized approach for auditing to determine the level of compliance of dietary supplement products to 21 CFR Part 111, as well as incorporating additional retailer requirements.


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As the voice of the U.S. standards and conformity assessment system, the American National Standards Institute (ANSI) empowers its members and constituents to strengthen the U.S. marketplace position in the global economy while helping to assure the safety and health of consumers and the protection of the environment.

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